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A medium throughput screen identifies let-7b as a modulator of ciliogenesis

April 09, 2018

On Wednesday, April 11th, please join Lorraine Fievet as she talks about "A medium throughput screen identifies let-7b as a modulator of ciliogenesis." She performed a medium throughput screen testing about 800 miRNA inhibitors in human retinal pigmented epithelial cells to identify miRNAs that could significantly induce or suppress ciliogenesis. The top candidate predicted to enhance ciliogenesis was let-7b which is mostly known for its role in developmental timing, differentiation and cell cycle. Ongoing work includes the confirmation of these findings in vivo to either deplete or augment let-7b using either genome editing or injection of a let-7b mimic in the developing zebrafish, respectively, followed by cellular- or organ-level phenotyping for ciliary defects.